Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology Abstract...
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Q134R – Mechanisms of Action
Q134R is a strong cytoprotective agent: at nanomolecular range, it protects neuronal cells against ROS- (reactive oxygen species) and Abeta- (amyloid beta) induced neuronal death, and restores mitochondrial functioning.
Q134R restores memory impairment caused by scopolamine or Abeta oligomers, by modulation of the GABAA gated Cl- channels, specific for extrasynaptic signalling in neurogliaform cells, belonging to a specialized type of interneurons, which modulates memory formation.
