Q134R – Mechanisms of Action
Q134R is a strong cytoprotective agent: at nanomolecular range, it protects neuronal cells against ROS- (reactive oxygen species) and Abeta- (amyloid beta) induced neuronal death, and restores mitochondrial functioning.
Q134R restores memory impairment caused by scopolamine or Abeta oligomers, by modulation of the GABAA gated Cl- channels, specific for extrasynaptic signalling in neurogliaform cells, belonging to a specialized type of interneurons, which modulates memory formation.
Q134R has inhibitory effects on NFATs: a family of calcineurin- (CN) dependent transcription factors linked to the multiple pathologic hallmarks that emerge during AD. Numerous studies show that inhibition of CN/NFAT signalling leads to beneficial effects on amyloid pathology, neuroinflammation, neuronal viability, synaptic physiology, and cognitive function in mouse models of AD.
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An interview on the origin and development of our clinical candidate Q134R, on future plans of Aperus Pharma, and on the challenges of treating Alzheimer’s disease is...Read more